Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rag1tm1.1Sadu
Name:	recombination activating 1; targeted mutation 1.1, Sandra Dueber
MGI ID:	MGI:4414763
Synonyms:	Indu-Rag1fl
Gene:	Rag1  Location: Chr2:101468627-101479846 bp, - strand  Genetic Position: Chr2, 53.88 cM
Alliance:	Rag1tm1.1Sadu page

Germline Transmission:	Earliest citation of germline transmission: J:155473
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	BALB/c

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The coding region in exon 2 was replaced with an FRT flanked neo cassette and an inverted coding region flanked by loxP sites in reverse orientation. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination is required to re-establish endogenous expression. (J:155473)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rag1 Mutation:	120 strains or lines available

Original:	J:155473 Duber S, et al., Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood. 2009 Dec 3;114(24):4960-7
All:	7 reference(s)