Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3catm3Bvan
Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 3, Bart Vanhaesebroeck
MGI ID:	MGI:3795787
Synonyms:	p110alphaflox
Gene:	Pik3ca  Location: Chr3:32451203-32520256 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Alliance:	Pik3catm3Bvan page

Germline Transmission:	Earliest citation of germline transmission: J:136236
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted downstream of exon 17 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 19. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 18 and 19 floxed. (J:136236)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:	62 strains or lines available

Original:	J:136236 Graupera M, et al., Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. 2008 May 29;453(7195):662-6
All:	22 reference(s)