Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Kdrtm1.1Jamb Name: kinase insert domain protein receptor; targeted mutation 1.1, Jayakrishna Ambati MGI ID: MGI:4367756 Synonyms: Vegfr2flox Gene: Kdr  Location: Chr5:76093487-76139118 bp, - strand  Genetic Position: Chr5, 40.23 cM Alliance: Kdrtm1.1Jamb page

Suppression of of extraretinal vascular outgrowth in ischemic Kdrtm1.1Jamb/Kdrtm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:154336
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Germ line, flp mediated recombination removes the neo cassette leaving exon 1 floxed. (J:154336)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:	71 strains or lines available

Original:	J:154336 Albuquerque RJ, et al., Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med. 2009 Sep;15(9):1023-30
All:	8 reference(s)