All Phenotypes Kdr<tm1.1Jamb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdr^tm1.1Jamb
targeted mutation 1.1, Jayakrishna Ambati
MGI:4367756

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4367769
cn2	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5052372
cn3	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR	MGI:4367768
cn4	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(KRT14-cre)1Efu/0	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:4367771

Allelic Composition	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to injury ( J:154336 )

• following intracorneal administration of a cre coding plasmid, mice exhibit an 161% increase in lymphangiogenesis but not hemangiogenesis in response to suture injury compared with mice injected with the empty vector

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

immune system

abnormal lymphangiogenesis ( J:154336 )

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

lymphatic vessel hyperplasia ( J:154336 )

• mice treated intracorneally with a cre coding plasmid fail to exhibit a decrease in lymphangiogenesis when expression of soluble Kdr unlike similarly treated wild-type mice

Allelic Composition	Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (71 available)
Kdr^tm1Jrt mutation (1 available); any Kdr mutation (71 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Suppression of of extraretinal vascular outgrowth in ischemic Kdr^tm1.1Jamb/Kdr^tm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

Allelic Composition	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (71 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cornea morphology ( J:154336 )

• at P0, corneas are densely covered with lymphatic vessels unlike in wild-type mice

• however, mice exhibit normal limbal blood vessels and corneal hemangiogenesis in response to suture injury

immune system

abnormal lymphatic vessel morphology ( J:154336 )

• hyperplastic lymphatic vessels in the cornea lack erythocytes, do not have a continuous basement membrane, and containing partly overlapping thin endothelial cells free of pericyte coverage unlike wild-type lymphatic vessels

lymphatic vessel hyperplasia ( J:154336 )

• at P0, corneas are densely covered with lymphatic vessels unlike in wild-type mice

cellular

abnormal basement membrane morphology ( J:154336 )

• hyperplastic lymphatic vessels in the cornea do not have a continuous basement membrane unlike wild-type lymphatic vessels

Allelic Composition	Kdr^tm1.1Jamb/Kdr^tm1.1Jamb Tg(KRT14-cre)1Efu/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdr^tm1.1Jamb mutation (0 available); any Kdr mutation (71 available)
Tg(KRT14-cre)1Efu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lymphatic vessel hyperplasia ( J:154336 )

• skin lymphatic vessels are dilated and hyperplastic compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23