Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fasltm1.1Ast
Name:	Fas ligand; targeted mutation 1.1, Andreas Strasser
MGI ID:	MGI:4366050
Synonyms:	FasLdeltam
Gene:	Fasl  Location: Chr1:161608260-161616064 bp, - strand  Genetic Position: Chr1, 69.95 cM
Alliance:	Fasltm1.1Ast page

Germline Transmission:	Earliest citation of germline transmission: J:153501
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The portion of the gene encoding the transmembrane and intra-cellular regions were replaced with the signal peptide of cytokine G-CSF. A floxed neo cassette used for selection purposes was removed by germ line, cre mediated recombination. This allele is incapable of producting the membrane bound version of the peptide but produces the soluble form. (J:153501)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:	36 strains or lines available

Original:	J:153501 O' Reilly LA, et al., Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009 Oct 1;461(7264):659-63
All:	5 reference(s)