Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox10Dal
Name:	SRY (sex determining region Y)-box 10; dalmatian
MGI ID:	MGI:3775949
Synonyms:	Sox10M1Btlr
Gene:	Sox10  Location: Chr15:79039113-79048690 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance:	Sox10Dal page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The mutaion is a T-to-G transversion at nucleotide position 676 of the gene (Genbank: XM_128139), in the second exon. It results in replacement of asparagine by lysine at amino acid position 131 (N131K), the terminal amino acid of the loop between the first and second alpha-helices (sometimes considered the first aa of helix II) in the DNA-binding HMG domain of the protein. (J:132358) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox10 Mutation:	33 strains or lines available

Original:	J:132358 Smart NG, et al., Dalmatian, a mouse white spotting coat color mutant allele of Sox10. MGI Direct Data Submission. 2008;
All:	1 reference(s)