Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sh2d1atm2Vei
Name:	SH2 domain containing 1A; targeted mutation 2, Andre Veillette
MGI ID:	MGI:3774546
Synonyms:	sapfl
Gene:	Sh2d1a  Location: ChrX:41591442-41610974 bp, + strand  Genetic Position: ChrX, 23.2 cM, cytoband A5
Alliance:	Sh2d1atm2Vei page

Germline Transmission:	Earliest citation of germline transmission: J:131618
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. The neo cassette ws removed by flp-mediated recombination. (J:131618)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1a Mutation:	10 strains or lines available

Original:	J:131618 Veillette A, et al., SAP expression in T cells, not in B cells, is required for humoral immunity. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1273-8
All:	2 reference(s)