Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wwtr1tm1Benj
Name:	WW domain containing transcription regulator 1; targeted mutation 1, Thomas Benjamin
MGI ID:	MGI:3759999
Synonyms:	TAZ-
Gene:	Wwtr1  Location: Chr3:57363070-57483331 bp, - strand  Genetic Position: Chr3, 27.74 cM
Alliance:	Wwtr1tm1Benj page

Germline Transmission:	Earliest citation of germline transmission: J:125326
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a SA-Betagal PGK-neo cassette such that the remaining open reading frame would be out of frame. Exon 2 encodes a 144 amino acid stretch containing the 14-3-3 binding domain and the WW domain. A western blot of protein extracts from mouse embryonic fibroblasts with a C-terminal antibody confirmed the absence of protein expression. (J:125326)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wwtr1 Mutation:	23 strains or lines available

Original:	J:125326 Tian Y, et al., TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007 Sep;27(18):6383-95
All:	10 reference(s)