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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wwtr1tm1Benj
targeted mutation 1, Thomas Benjamin
MGI:3759999
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wwtr1tm1Benj/Wwtr1tm1Benj 129S-Wwtr1tm1Benj/J MGI:4420930
hm2
 		Wwtr1tm1Benj/Wwtr1tm1Benj 129S6/SvEvTac-Wwtr1tm1Benj MGI:3760003


Genotype
MGI:4420930
hm1
Allelic
Composition		 Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic
Background		 129S-Wwtr1tm1Benj/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wwtr1tm1Benj mutation (1 available); any Wwtr1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:156586 )
• female mice usually succumb before breeding age
prenatal lethality, incomplete penetrance ( J:156586 )
• only 10% to 25% of the expected mice are born

reproductive system
reduced female fertility ( J:156586 )
• successful breeding of female mice is uncommon

growth/size/body
polycystic kidney ( J:156586 )
• onset as early as a few weeks of age
decreased body size ( J:156586 )
enlarged kidney ( J:156586 )
• with age

behavior/neurological

renal/urinary system
polycystic kidney ( J:156586 )
• onset as early as a few weeks of age
enlarged kidney ( J:156586 )
• with age

respiratory system
lung inflammation ( J:156586 )
• in some mice
abnormal pulmonary alveolus wall morphology ( J:156586 )
• breakdown of alveolar walls
emphysema ( J:156586 )
• mice exhibit swollen alveoli and breakdown of alveolar walls

digestive/alimentary system
intestinal inflammation ( J:156586 )
• in some mice

immune system
intestinal inflammation ( J:156586 )
• in some mice
lung inflammation ( J:156586 )
• in some mice

adipose tissue




Genotype
MGI:3760003
hm2
Allelic
Composition		 Wwtr1tm1Benj/Wwtr1tm1Benj
Genetic
Background		 129S6/SvEvTac-Wwtr1tm1Benj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wwtr1tm1Benj mutation (1 available); any Wwtr1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:125326 )
• only half of the expected number of mice are born

renal/urinary system
kidney cortex cyst ( J:125326 )
• mice develop severe polycystic renal disease with cysts of varying sizes scattered throughout the cortex
• cysts are bilateral, appear at day 18 at the earliest, are lined with cuboidal epithelium with scanty cytoplasm and are frequently filled with homogeneous eosinopilic fluid or small amounts of floccular material
• cysts and kidney size increase with age
• however, mice do not develop cysts in the salivary glands, pancreas, liver or other glandular organs
polycystic kidney ( J:125326 )
• mice develop severe polycystic renal disease
enlarged kidney ( J:125326 )
• kidney size increases with age
hydronephrosis ( J:125326 )
• mice exhibit dilation of the renal pelvis at a young age

respiratory system
lung inflammation ( J:125326 )
• lung inflammation is observed in some 2- to 4-week old mice
abnormal pulmonary alveolus wall morphology ( J:125326 )
• breakdown of alveolar walls
emphysema ( J:125326 )
• mice develop emphysema associated with swollen alveoli and breakdown of alveolar walls

immune system
intestinal inflammation ( J:125326 )
• intestinal inflammation is observed in some 2- to 4-week old mice
lung inflammation ( J:125326 )
• lung inflammation is observed in some 2- to 4-week old mice

adipose tissue
decreased fat cell size ( J:125326 )
• adipocytes are smaller in size than in wild-type mice

behavior/neurological

growth/size/body
kidney cortex cyst ( J:125326 )
• mice develop severe polycystic renal disease with cysts of varying sizes scattered throughout the cortex
• cysts are bilateral, appear at day 18 at the earliest, are lined with cuboidal epithelium with scanty cytoplasm and are frequently filled with homogeneous eosinopilic fluid or small amounts of floccular material
• cysts and kidney size increase with age
• however, mice do not develop cysts in the salivary glands, pancreas, liver or other glandular organs
polycystic kidney ( J:125326 )
• mice develop severe polycystic renal disease
decreased body size ( J:125326 )
enlarged kidney ( J:125326 )
• kidney size increases with age

digestive/alimentary system
intestinal inflammation ( J:125326 )
• intestinal inflammation is observed in some 2- to 4-week old mice




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory