Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cdk4tm2Bbd
Name:	cyclin dependent kinase 4; targeted mutation 2, Mariano Barbacid
MGI ID:	MGI:3759557
Synonyms:	Cdk43frt
Gene:	Cdk4  Location: Chr10:126899404-126903157 bp, + strand  Genetic Position: Chr10, 74.5 cM, cytoband D3
Alliance:	Cdk4tm2Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:125217
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt site was inserted 230 bp upstream of exon 2 and a PGK-hygromycin cassette flanked by frt sites was inserted 115 bp downstream of exon 4. The targeting vector was electroporated into ES cells already carrying the conditional Cdk2tm2.1Sgo allele and integrated into the same chromosome. (J:125217)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk4 Mutation:	57 strains or lines available

Original:	J:125217 Barriere C, et al., Mice thrive without Cdk4 and Cdk2. Mol Oncol. 2007 Jun;1(1):72-83
All:	1 reference(s)