Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gli3tm2Blnw
Name:	GLI-Kruppel family member GLI3; targeted mutation 2, Baolin Wang
MGI ID:	MGI:3711052
Synonyms:	Gli3P1-4
Gene:	Gli3  Location: Chr13:15638308-15904611 bp, + strand  Genetic Position: Chr13, 5.43 cM, cytoband A2
Alliance:	Gli3tm2Blnw page

Germline Transmission:	Earliest citation of germline transmission: J:121609
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Genomic sequence including residues 846-914 were replaced with the corresponding human cDNA containing S to A mutations at the first four PKA sites. A floxed neo included in the vector was removed via cre mediated recombination. (J:121609)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gli3 Mutation:	80 strains or lines available

Original:	J:121609 Wang C, et al., The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol. 2007 May 15;305(2):460-9
All:	3 reference(s)