All Phenotypes Gli3<tm2Blnw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli3^tm2Blnw
targeted mutation 2, Baolin Wang
MGI:3711052

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli3^tm2Blnw/Gli3^tm2Blnw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3711905
ht2	Gli3^tm2Blnw/Gli3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3711902
ht3	Gli3^tm1Urt/Gli3^tm2Blnw	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:6149471
cx4	Gli3^tm2Blnw/Gli3⁺ Shh^tm1Chg/Shh^tm1Chg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3711913

Allelic Composition	Gli3^tm2Blnw/Gli3^tm2Blnw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm2Blnw mutation (0 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121609 )

• mice die mostly before birth and those that are born die soon after

limbs/digits/tail

abnormal digit morphology ( J:121609 )

• at birth, all of the digits consist of only two very short phalanges with the proximal ones being split with abnormal ossification

abnormal phalanx morphology ( J:121609 )

• at E16.5, in some mice phalanges lack ossification

• at birth, phalanges are short and proximal ones are split

• extra phalanges element branch from the metatarsals

polydactyly ( J:121609 )

• at E16.5, mice have 6 to 8 digits that lack identity

absent tibia ( J:121609 )

• at E16.5

short tibia ( J:121609 )

• when present, tibia is shorter

skeleton

abnormal phalanx morphology ( J:121609 )

• at E16.5, in some mice phalanges lack ossification

• at birth, phalanges are short and proximal ones are split

• extra phalanges element branch from the metatarsals

absent tibia ( J:121609 )

• at E16.5

short tibia ( J:121609 )

• when present, tibia is shorter

synostosis ( J:121609 )

• at E16.5, in some mice a ring-shaped ossification forms interdigitally

• at birth ossification between digits is located between the distal phalanges

Allelic Composition	Gli3^tm2Blnw/Gli3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm2Blnw mutation (0 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:121609 )

• complete duplication of first digit on each limb

• however, digit identity is normal

Allelic Composition	Gli3^tm1Urt/Gli3^tm2Blnw
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1Urt mutation (0 available); any Gli3 mutation (80 available)
Gli3^tm2Blnw mutation (0 available); any Gli3 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:121609 )

• mice have extra d1 digit

Allelic Composition	Gli3^tm2Blnw/Gli3⁺ Shh^tm1Chg/Shh^tm1Chg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm2Blnw mutation (0 available); any Gli3 mutation (80 available)
Shh^tm1Chg mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:121609 )

• limb phenotypes are indistinguishable to those seen in Gli3^tm2Blnw homozygotes

abnormal autopod morphology ( J:121609 )

• digit identity is partially restored with 3 or 4 digits clearly mimicking digits 2 to 4 or 2 to 5 identities

• limb phenotypes are indistinguishable to those seen in Gli3^tm2Blnw homozygotes

abnormal digit morphology ( J:121609 )

• limb phenotypes are indistinguishable to those seen in Gli3^tm2Blnw homozygotes

abnormal phalanx morphology ( J:121609 )

• some digits have shortened phalanges

polydactyly ( J:121609 )

• digit 1 is sometimes duplicated

absent tibia ( J:121609 )

short tibia ( J:121609 )

skeleton

abnormal phalanx morphology ( J:121609 )

• some digits have shortened phalanges

absent tibia ( J:121609 )

short tibia ( J:121609 )

synostosis ( J:121609 )

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