Tyr<c-e> Spontaneous Allele Detail MGI Mouse (MGI:1855978)

Tyr^c-e
Spontaneous Allele Detail

Summary

Symbol:	Tyr^c-e
Name:	tyrosinase; extreme dilution
MGI ID:	MGI:1855978
Synonyms:	c^d, c^e
Gene:	Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
Alliance:	Tyr^c-e page

Mutation
origin

Strain of Origin:

wild

Mutation
description

Allele Type:		Spontaneous
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available Cell Lines: 0 lines available
Carrying any Tyr Mutation:	375 strains or lines available

Notes

Tyr^c-e, extreme dilution. This mutation was found in the wild by Detlefsen (J:34484). Hair is very light gray, and eyes are black. Melanin granules of both retinal and neural-crest derived melanocytes are pigmented but are smaller and fewer than normal (J:12970, J:5001). Tyrosinase activity in the skin is very low (J:30744). Tyr^c-e/Tyr^c mice are almost white with black eyes.

References

Original:	J:34484 Detlefsen JA, A new mutation in the house mouse. Am Naturalist. 1921 Sep-Oct;55:469-73
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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