Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wt1tm2Vih
Name:	WT1 transcription factor; targeted mutation 2, Vicki Huff
MGI ID:	MGI:3665320
Synonyms:	Wt1flox, Wt1fx
Gene:	Wt1  Location: Chr2:104956874-105003959 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Alliance:	Wt1tm2Vih page

Germline Transmission:	Earliest citation of germline transmission: J:111787
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exons 8 and 9 were flanked by loxP sites and a neo resistance cassette with a loxP site was inserted downstream of the floxed exons via homologous recombination. The neo cassette was removed by mating with CMV-Cre transgenic mice. (J:111787)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:	34 strains or lines available

Original:	J:111787 Gao F, et al., The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
All:	22 reference(s)