Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd4del
Name:	CD4 antigen; deletion
MGI ID:	MGI:3664575
Gene:	Cd4  Location: Chr6:124841655-124865184 bp, - strand  Genetic Position: Chr6, 59.17 cM
Alliance:	Cd4del page

Strain of Origin:

C57BR/cdJ

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: Sequence analysis revealed that one thymine was substituted for the 14 bp at the junction between exon VIII and intron VIII. This results in the skipping of exon 8 in the expressed transcript, resulting in a deletion of the transmembrane domain and C-terminus of the encoded protein. Soluble Cd4 is detectable in the sera of mutant mice. (J:46692)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd4 Mutation:	82 strains or lines available

Original:	J:46692 Nagase H, et al., Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4. Eur J Immunol. 1998 Feb;28(2):403-12
All:	2 reference(s)