Phenotypes associated with this allele

• Allele Symbol: Cd4^del
• Allele Name: deletion
• Allele ID: MGI:3664575
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd4^del/Cd4^del	C57BR/cdJ-Cd4^del	MGI:3688417

Genotype
MGI:3688417

hm1

• Allelic Composition: Cd4^del/Cd4^del
• Genetic Background: C57BR/cdJ-Cd4^del

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

absent CD4-positive, alpha-beta T cells ( J:46692 )

• no Cd4+ thymocytes detectable

increased CD8-positive, alpha-beta T cell number ( J:46692 )

• increased number of single positive Cd8 cells compared to normal

decreased immunoglobulin level ( J:46692 )

• after injection with T-cell dependent antigens

decreased IgG level ( J:46692 )

• with immunization using keyhole limpet hemocyanin, only small amounts of IgG1 and IgG3, no IgG2a and IgG2b but normal amounts of IgM

• with immunization using sheep red blood cells, 100X reduction in IgG

decreased IgM level ( J:46692 )

• 100X reduction in IgM using sheep red blood cells

abnormal immune system organ morphology ( J:46692 )

abnormal spleen morphology ( J:46692 )

• space normally occupied by single positive Cd4 now occupied by single positive Cd8 cells

abnormal lymph node T cell domain morphology ( J:46692 )

• space normally occupied by single positive Cd4 now occupied by single positive Cd8 cells

hematopoietic system

absent CD4-positive, alpha-beta T cells ( J:46692 )

• no Cd4+ thymocytes detectable

increased CD8-positive, alpha-beta T cell number ( J:46692 )

• increased number of single positive Cd8 cells compared to normal

abnormal spleen morphology ( J:46692 )

• space normally occupied by single positive Cd4 now occupied by single positive Cd8 cells

decreased immunoglobulin level ( J:46692 )

• after injection with T-cell dependent antigens

decreased IgG level ( J:46692 )

• with immunization using keyhole limpet hemocyanin, only small amounts of IgG1 and IgG3, no IgG2a and IgG2b but normal amounts of IgM

• with immunization using sheep red blood cells, 100X reduction in IgG

decreased IgM level ( J:46692 )

• 100X reduction in IgM using sheep red blood cells