Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abcb1btm2Bor
Name:	ATP-binding cassette, sub-family B member 1B; targeted mutation 2, Piet Borst
MGI ID:	MGI:2155889
Synonyms:	mdr1b-
Gene:	Abcb1b  Location: Chr5:8848147-8916314 bp, + strand  Genetic Position: Chr5, 3.43 cM, cytoband A2-A3
Alliance:	Abcb1btm2Bor page

Germline Transmission:	Earliest citation of germline transmission: J:39804
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 3 and 4 was deleted and replaced with a neomycin selection cassette. These sequences encode the first putative transmembrane segment and flanking sequences. This mutation also introduces a frameshift and any protein produced from this allele is predicted to be nonfunctional. (J:39804)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcb1b Mutation:	84 strains or lines available

Original:	J:39804 Schinkel AH, et al., Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4028-33
All:	2 reference(s)