All Phenotypes Abcb1b<tm2Bor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Abcb1b^tm2Bor
targeted mutation 2, Piet Borst
MGI:2155889

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcb1b^tm2Bor/Abcb1b^tm2Bor	involves: 129P2/OlaHsd * FVB	MGI:2386645

Allelic Composition	Abcb1b^tm2Bor/Abcb1b^tm2Bor
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb1b^tm2Bor mutation (0 available); any Abcb1b mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:39804 )

• altered pharmacokinetics of digoxin, with reduced elimination (and thus accumulation) of digoxin in adrenal glands and ovaries but not any other tissue

• rate of rhodamine efflux from hematopoietic progenitor cells is diminished

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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