Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Chd4tm1Kge
Name:	chromodomain helicase DNA binding protein 4; targeted mutation 1, Katia Georgopoulos
MGI ID:	MGI:3653109
Synonyms:	Mi-2BLoxPNeo+
Gene:	Chd4  Location: Chr6:125073144-125107554 bp, + strand  Genetic Position: Chr6, 59.28 cM
Alliance:	Chd4tm1Kge page

Germline Transmission:	Earliest citation of germline transmission: J:109547
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert loxP sites to flank exons 12 through 21 of the locus. Frt sites flanked a neo included in the vector in intron 11. The floxed locus encompasses the ATPase domain, required for the remodeling activity. Splicing of exon 11 to exon 22 would putatively generate an out of frame transcript, possibly resulting in a truncated protein. (J:109547)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chd4 Mutation:	58 strains or lines available

Original:	J:109547 Williams CJ, et al., The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity. 2004 Jun;20(6):719-33
All:	1 reference(s)