Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zap70mrtle
Name:	zeta-chain (TCR) associated protein kinase; mr t-less
MGI ID:	MGI:3614790
Synonyms:	Zap70mrt
Gene:	Zap70  Location: Chr1:36800879-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70mrtle page

Strain of Origin:	C57BL/6JSfdAnu
Project Collection:	APF ENU Mutagenesis

Allele Type:    Chemically induced (ENU) (Hypomorph) Mutation:    Single point mutation   Mutation details: This phenotypic mutation, identified in an ENU mutagenesis screen, is a T-to-C transition at nucleotide position 1601 that results in replacement of tryptophan by arginine at amino acid position 504 of the protein (W504R), which resides in the kinase domain. The level of the protein in homozygous and heterozygous mutant thymocytes is approximately 25% and 50% that in wild-type thymocytes, respectively. Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

Original:	J:104190 The Australian Phenomics Facility at The Australian National University, Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University. MGI Direct Data Submission. 2006-2014;
All:	6 reference(s)