All Phenotypes Zap70<mrtle> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zap70^mrtle/Zap70^mrtle	C57BL/6JSfdAnu-Zap70^mrtle/Apb	MGI:3615426
hm2	Zap70^mrtle/Zap70^mrtle	involves: C57BL/6JSfdAnu	MGI:5576561
ht3	Zap70^mrtle/Zap70^rps	involves: C57BL/6 * C57BL/6JSfdAnu	MGI:5576560

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:104190 )

• failure of positive selection in the thymus

arrested T cell differentiation ( J:104190 )

• normal numbers of both double negative (DN) and double positive (DP) thymocytes in homozygous mutant mice, despite near-absence of both CD4⁺ CD8^- and CD4^- CD8⁺ single positive (SP) T cells in peripheral blood, indicates a block at the transition from the DP to the SP stage, in turn indicating failure of positive selection in the thymus

• the block in mutant T cell develoopment was shown to be cell-intrinsic, not due to the thymic microenvironment

• T cells of mutant mice are unable to pass through thymic selection steps

• T cells of mutant mice fail to up-regulate their TCRs

abnormal T cell subpopulation ratio ( J:104190 )

• although total T cell counts are very low and alpha/beta T cells are virtually absent, gamma/delta T cell numbers are elevated in the peripheral blood of mutant mice

decreased T cell number ( J:104190 )

• homozygous mutant mice are characterized by a severe reduction in the number of T cells in their blood; both CD4⁺ CD8^- and CD4^- CD8⁺ single positive (SP) T cells are almost entirely absent

absent T cells ( J:104190 )

• alpha/beta T cells are absent in the peripheral blood of mutant mice

hematopoietic system

abnormal positive T cell selection ( J:104190 )

• failure of positive selection in the thymus

arrested T cell differentiation ( J:104190 )

• the block in mutant T cell develoopment was shown to be cell-intrinsic, not due to the thymic microenvironment

• T cells of mutant mice are unable to pass through thymic selection steps

• T cells of mutant mice fail to up-regulate their TCRs

abnormal T cell subpopulation ratio ( J:104190 )

• although total T cell counts are very low and alpha/beta T cells are virtually absent, gamma/delta T cell numbers are elevated in the peripheral blood of mutant mice

decreased T cell number ( J:104190 )

• homozygous mutant mice are characterized by a severe reduction in the number of T cells in their blood; both CD4⁺ CD8^- and CD4^- CD8⁺ single positive (SP) T cells are almost entirely absent

absent T cells ( J:104190 )

• alpha/beta T cells are absent in the peripheral blood of mutant mice

Allelic Composition	Zap70^mrtle/Zap70^mrtle
Genetic Background	involves: C57BL/6JSfdAnu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^mrtle mutation (5 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• absent Foxp3+ regulatory T cells within CD4+ single positive thymocytes and lymphocytes in the spleen

hematopoietic system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• absent Foxp3+ regulatory T cells within CD4+ single positive thymocytes and lymphocytes in the spleen

Allelic Composition	Zap70^mrtle/Zap70^rps
Genetic Background	involves: C57BL/6 * C57BL/6JSfdAnu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70^mrtle mutation (5 available); any Zap70 mutation (55 available)
Zap70^rps mutation (0 available); any Zap70 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes

• percent of Foxp3+ regulatory T cells within CD4+ single positive lymphocytes in the spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )

• CD4+ T cells exhibit blockage of calcium signaling compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

hematopoietic system

abnormal double-positive T cell morphology ( J:211510 )

• reduced frequency of post-selection CD69+ double positive thymocytes

increased double-positive T cell number ( J:211510 )

decreased CD8-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

abnormal regulatory T cell number ( J:211510 )

• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes

• percent of Foxp3+ regulatory T cells within CD4+ single positive lymphocytes in the spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )

• CD4+ T cells exhibit blockage of calcium signaling compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:211510 )

• reduced percent in the percent thymus and spleen

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