Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apoetm3(APOE_i3)Sfu
Name:	apolipoprotein E; targeted mutation 1, Shinobu C Fujita
MGI ID:	MGI:3610994
Synonyms:	3/3, apoE3, ApoE3-KI, Apoetm1(APOE)Kyan, Apoetm3(APOE3)sfu
Gene:	Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance:	Apoetm3(APOE_i3)Sfu page

Germline Transmission:	Earliest citation of germline transmission: J:103515
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Apoetm3(APOE_i3)Sfu expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human APOE (348) Apoe  (MGI:88057) Expresses the epsilon3 isoform   Mutation details: A portion of the endogenous locus, spanning from within exon 2 through most of exon 4, was replaced by the human cDNA encoding APOE isoform 3. Mouse protein was not detected in Western blot of mutants. Human protein was shown to be robustly expressed. (J:103515)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:	145 strains or lines available

Original:	J:103515 Hayashi H, et al., Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice. Neuroreport. 2002 Mar 25;13(4):383-6
All:	8 reference(s)