Phenotypes associated with this allele

• Allele Symbol: Apoe^{tm3(APOE_i3)Sfu}
• Allele Name: targeted mutation 1, Shinobu C Fujita
• Allele ID: MGI:3610994
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoe^tm3(APOE_i3)Sfu/Apoe^tm3(APOE_i3)Sfu	involves: 129P2/OlaHsd	MGI:3616187
cx2	Apoe^tm3(APOE_i3)Sfu/Apoe^tm3(APOE_i3)Sfu Tg(APPSWE)2576Kha/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:6450214

Genotype
MGI:3616187

hm1

• Allelic Composition: Apoe^{tm3(APOE_i3)Sfu}/Apoe^{tm3(APOE_i3)Sfu}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:103515 )

N • cholesterol distribution within the synaptic plasma membrane does not differ from wild-type

decreased circulating cholesterol level ( J:104859 )

• serum cholesterol level is lower than in knock-ins expressing human APOE4 or APOE2

abnormal response to CNS ischemic injury ( J:104859 )

• infarct area is smaller than knock-ins expressing human apoE4

nervous system

abnormal response to CNS ischemic injury ( J:104859 )

• infarct area is smaller than knock-ins expressing human apoE4

Genotype
MGI:6450214

cx2

• Allelic Composition: Apoe^{tm3(APOE_i3)Sfu}/Apoe^{tm3(APOE_i3)Sfu}; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:121533 )

♂N • amyloid beta deposits are scarcely seen at 15-16 months of age compared to the many in single Tg(APPSWE)2576Kha/0 mice