Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Efemp2tm1Dgen Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2; targeted mutation 1, Deltagen MGI ID: MGI:3604551 Synonyms: Fbln4-, fibulin-4- Gene: Efemp2  Location: Chr19:5523982-5532545 bp, + strand  Genetic Position: Chr19, 4.33 cM, cytoband A Alliance: Efemp2tm1Dgen page

Efemp2tm1Dgen/Efemp2+ mice exhibit abnormal aorta morphology Show the 1 phenotype image(s) involving this allele.

Mutant Cell Line:	2561
Germline Transmission:	Earliest citation of germline transmission: J:101679
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. While RT-PCR analysis detects a gene transcript in all tissues tested, strong beta-galactosidase expression from this allele is detectable in brain, spinal cord, eyes, Harderian glands, thymus, spleen, lymph nodes, aorta, heart, lung, liver, gallbladder, pancreas, kidney, urinary bladder, trachea, larynx, esophagus, thyroid gland, pituitary gland, adrenal glands, salivary glands, tongue, skeletal muscle, skin, male and female reproductive systems. In many tissues lacZ is expressed in smooth muscle cells.

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	123 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Efemp2 Mutation:	26 strains or lines available

Original:	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	8 reference(s)