Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol: Spred2Gt(XB228)Byg Name: sprouty-related EVH1 domain containing 2; gene trap XB228, BayGenomics MGI ID: MGI:3590299 Synonyms: Spred-2-, Spred2Gt(pGTO)1Ksch Gene: Spred2  Location: Chr11:19874442-19974026 bp, + strand  Genetic Position: Chr11, 12.79 cM, cytoband A3.2 Alliance: Spred2Gt(XB228)Byg page

Achondroplasia-like dwarfism in Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg mice Show the 2 phenotype image(s) involving this allele.

Mutant Cell Line:	XB228
Germline Transmission:	Earliest citation of germline transmission: J:100826
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT0pfs     Vector Type: gene trap   Mutation details: A gene trap vector, pGTO, containing a splice acceptor, Betageo and SV40 pA sequence, inserted into intron 4 of the locus. RT-PCR failed to detect transcript in all tissues tested. Northern blot and Western blot confirmed lack of all forms of transcript and protein in mutant brain samples, respectively. (J:100826) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select XB228 CC144423 (MGI Seq Detail) 5' RACE Chr11:19948166-19958475 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 222 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	368 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spred2 Mutation:	221 strains or lines available

Original:	J:100826 Bundschu K, et al., Gene disruption of Spred-2 causes dwarfism. J Biol Chem. 2005 Aug 5;280(31):28572-80
All:	8 reference(s)