Phenotypes associated with this allele

• Allele Symbol: Spred2^Gt(XB228)Byg
• Allele Name: gene trap XB228, BayGenomics
• Allele ID: MGI:3590299
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spred2^Gt(XB228)Byg/Spred2^Gt(XB228)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3603325

Genotype
MGI:3603325

hm1

• Allelic Composition: Spred2^Gt(XB228)Byg/Spred2^Gt(XB228)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Achondroplasia-like dwarfism in Spred2^Gt(XB228)Byg/Spred2^Gt(XB228)Byg mice

growth/size/body

decreased body weight ( J:100826 )

decreased body length ( J:100826 )

• smaller at birth and stay small throughout life, however levels of testosterone, estrogen, thyroid stimulating hormone, and thyroxin are normal

disproportionate dwarf ( J:100826 )

• more pronounced in males than females, although seen in both

reproductive system

decreased litter size ( J:100826 )

• average litter size is 4.4 pups compared to 8.4 pups in wild-type

hematopoietic system

increased megakaryocyte cell number ( J:100826 )

• increase in number of megakaryocytes in the spleen

skeleton

short tibia ( J:100826 )

decreased width of hypertrophic chondrocyte zone ( J:100826 )

decreased long bone epiphyseal plate size ( J:100826 )

• narrower growth plate

limbs/digits/tail

short tibia ( J:100826 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
achondroplasia		DOID:4480	OMIM:100800	J:100826