Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gata1tm8.1Sho
Name:	GATA binding protein 1; targeted mutation 8.1, Stuart H Orkin
MGI ID:	MGI:3582685
Synonyms:	Gata1deltaefl
Gene:	Gata1  Location: ChrX:7825504-7842844 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Alliance:	Gata1tm8.1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:99310
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An AvrII-NheI genomic fragment spanning exon 2 and part of exon 3 was amplified. Then a 5' loxP site was introduced to the AvrII site and a neo cassette was inserted into the PstI site in the intron between exons 2 and 3. The neo cassette was later removed by transfecting a GFP-Cre plasmid and then carrying out fluorescence-activated cell sorting for GFP+ cells, leaving exon 2 flanked by loxP sites. (J:99310)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:	44 strains or lines available

Original:	J:99310 Li Z, et al., Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005 Jun;37(6):613-9
All:	1 reference(s)