Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sod2tm1.1Kskk
Name:	superoxide dismutase 2, mitochondrial; targeted mutation 1.1, Karin Scharffetter-Kochanek
MGI ID:	MGI:3578627
Synonyms:	Sod2-
Gene:	Sod2  Location: Chr17:13226726-13237006 bp, + strand  Genetic Position: Chr17, 8.75 cM
Alliance:	Sod2tm1.1Kskk page

Germline Transmission:	Earliest citation of germline transmission: J:98289
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 3, which encodes 39 amino acids responsible for homodimerization, tetramer formation and manganese binding, was removed via cre-mediated recombination. (J:98289)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod2 Mutation:	24 strains or lines available

Original:	J:98289 Strassburger M, et al., Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 2005 Jun 1;38(11):1458-70
All:	4 reference(s)