Phenotypes associated with this allele

• Allele Symbol: Sod2^tm1.1Kskk
• Allele Name: targeted mutation 1.1, Karin Scharffetter-Kochanek
• Allele ID: MGI:3578627
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sod2^tm1.1Kskk/Sod2^tm1.1Kskk	involves: 129P2/OlaHsd * C57BL/6	MGI:3580872
ht2	Sod2^tm1.1Kskk/Sod2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3580873

Genotype
MGI:3580872

hm1

• Allelic Composition: Sod2^tm1.1Kskk/Sod2^tm1.1Kskk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:98289 )

• die 8 -10 days after birth

cardiovascular system

abnormal myocardial fiber morphology ( J:98289 )

• extensive lipid peroxidation is seen in the myocardium at 3 days after birth

growth/size/body

postnatal growth retardation ( J:98289 )

• severe growth retardation

behavior/neurological

fatigue ( J:98289 )

• fatigue rapidly

cellular

oxidative stress ( J:98289 )

• extensive lipid peroxidation is seen in the myocardium at 3 days after birth

muscle

abnormal myocardial fiber morphology ( J:98289 )

• extensive lipid peroxidation is seen in the myocardium at 3 days after birth

Genotype
MGI:3580873

ht2

• Allelic Composition: Sod2^tm1.1Kskk/Sod2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cardiovascular system

abnormal myocardial fiber morphology ( J:98289 )

• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age

abnormal myocardial fiber mitochondrial morphology ( J:98289 )

• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age

• mitochondrial clustering is seen in heterozygous hearts at 10 days of age

cellular

abnormal myocardial fiber mitochondrial morphology ( J:98289 )

• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age

• mitochondrial clustering is seen in heterozygous hearts at 10 days of age

increased cardiomyocyte apoptosis ( J:98289 )

• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells

oxidative stress ( J:98289 )

• increased formation of nitrotyrosine is seen in the myocardium of 3 and 10 day old heterozygotes

• clusters of cardiomyocytes show signs of lipid peroxidation in 7 out of 10 heterozygotes at 10 days of age

muscle

abnormal myocardial fiber morphology ( J:98289 )

• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age

abnormal myocardial fiber mitochondrial morphology ( J:98289 )

• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age

• mitochondrial clustering is seen in heterozygous hearts at 10 days of age

increased cardiomyocyte apoptosis ( J:98289 )

• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells