Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1.1Kskk mutation
(0 available);
any
Sod2 mutation
(24 available)
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mortality/aging
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• die 8 -10 days after birth
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cardiovascular system
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• extensive lipid peroxidation is seen in the myocardium at 3 days after birth
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growth/size/body
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• severe growth retardation
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behavior/neurological
cellular
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• extensive lipid peroxidation is seen in the myocardium at 3 days after birth
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muscle
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• extensive lipid peroxidation is seen in the myocardium at 3 days after birth
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Allelic
Composition |
Sod2tm1.1Kskk/Sod2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1.1Kskk mutation
(0 available);
any
Sod2 mutation
(24 available)
|
|
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cardiovascular system
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• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age
• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age
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• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells
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cellular
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• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells
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• increased formation of nitrotyrosine is seen in the myocardium of 3 and 10 day old heterozygotes
• clusters of cardiomyocytes show signs of lipid peroxidation in 7 out of 10 heterozygotes at 10 days of age
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muscle
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• accumulation of lipid droplets and mitochondrial clustering is seen in heterozygous hearts at 10 days of age
• swelling and disruption of mitochondrial membranes was seen in 7 out of 10 hearts at 10 days of age
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• at 6 and to a greater extent at 10 days after birth signs of apoptosis were detected in cardiomyocytes and endocardial cells
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Analysis Tools