Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Ambntm1Nid Name: ameloblastin; targeted mutation 1, Yoshihiko Yamada MGI ID: MGI:3525231 Synonyms: Ambn-, AMBNdelta5-6 Gene: Ambn  Location: Chr5:88603850-88616390 bp, + strand  Genetic Position: Chr5, 43.63 cM Alliance: Ambntm1Nid page

Defects in enamel formation of Ambntm1Nid/Ambntm1Nid mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:94844
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo replaced a genomic fragment extending from the XbaI site at Chr5:88889874 (Build 37) in intron 4 to the EcoRI site at Chr5:88893057 in intron 6. Both exons 5 and 6 are thus deleted. Neither transcript nor protein was detected in mutant mice. (Additional information provided by authors.) (J:94844)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

List all tumor models in MMHCdb carrying Ambntm1Nid

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ambn Mutation:	32 strains or lines available

Original:	J:94844 Fukumoto S, et al., Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol. 2004 Dec 6;167(5):973-83
All:	7 reference(s)