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Sox15tm1Imad
Targeted Allele Detail
Nomenclature
Symbol: Sox15tm1Imad
Name: SRY (sex determining region Y)-box 15; targeted mutation 1, Ibrahim M Adham
MGI ID: MGI:3056078
Synonyms: Sox15-
Gene: Sox15  Location: Chr11:69655314-69656727 bp, + strand  Genetic Position: Chr11, 42.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93031
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced a 2.5-kb fragment containing the 5' flanking region and part of exon 1, including sequence encoding the HMG domain. Northern and Western blot analyses confirmed inactivation of the gene. (J:93031)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox15 Mutation:  14 strains or lines available
References
Original:  J:93031 Lee HJ, et al., Sox15 is required for skeletal muscle regeneration. Mol Cell Biol. 2004 Oct;24(19):8428-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory