Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr3c1tm3Gsc
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 3, Gunther Schutz
MGI ID:	MGI:1931329
Synonyms:	GRD, GRdim
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm3Gsc page

Germline Transmission:	Earliest citation of germline transmission: J:67720
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion, Nucleotide substitutions   Mutation details: A point mutation was introduced into exon 4 to change alanine codon 474 to threonine (p.A474T). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 3 was removed via Cre-mediated recombination in ES cells prior to blastocyst injection. This mutation causes a defect in GRE-mediated transactivation and prevents dimerization. (J:67720, J:121199)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:67720 Reichardt HM, et al., DNA binding of the glucocorticoid receptor is not essential for survival. Cell. 1998 May 15;93(4):531-41
All:	42 reference(s)