Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Spi1tm1Dgt
Name:	Spi-1 proto-oncogene; targeted mutation 1, Daniel G Tenen
MGI ID:	MGI:3045206
Synonyms:	-14kbUREloxp+neo, (frt-PGKneo-frt--loxp-URE-loxp)
Gene:	Spi1  Location: Chr2:90912750-90946104 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Alliance:	Spi1tm1Dgt page

Germline Transmission:	Earliest citation of germline transmission: J:90331
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An Frt flanked neomycin cassette followed by a loxP site was inserted just 5' to the upstream regulatory element. The upstream regulatory element was then followed by another loxP site. (J:90331)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:	27 strains or lines available

Original:	J:90331 Rosenbauer F, et al., Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet. 2004 Jun;36(6):624-30
All:	2 reference(s)