Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sigmar1tm1Lmon
Name:	sigma non-opioid intracellular receptor 1; targeted mutation 1, Lluis Montoliu
MGI ID:	MGI:3044771
Synonyms:	mSR1-, Sig1R-, sigma1R KO
Gene:	Sigmar1  Location: Chr4:41738493-41741359 bp, - strand  Genetic Position: Chr4, 22.05 cM, cytoband A5-B2
Alliance:	Sigmar1tm1Lmon page

Germline Transmission:	Earliest citation of germline transmission: J:89669
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An in-frame lacZ gene and neo cassette were inserted after the first 4 codons deleting 1907 bases via homologous recombination. Northern and western blot analysis confirmed the absence of mRNA and protein expression in homozygous mice. (J:89669)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

10 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sigmar1 Mutation:	20 strains or lines available

Original:	J:89669 Langa F, et al., Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice. Eur J Neurosci. 2003 Oct;18(8):2188-96
All:	23 reference(s)