About   Help   FAQ
Ppargtm1.1Auw
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm1.1Auw
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Johan Auwerx
MGI ID: MGI:2683413
Synonyms: PPARgammaPro12Ala
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsThe frt flanked neomycin selection cassette was excised from Ppargtm1Auw via FLP mediated recombination. The proline to alanine missense mutation at codon 12 (exon B) was left intact. The levels of both Pparg1 and Pparg2 transcript in homozygous mutant mice did not significantly differ from those of wild-type. (J:86705)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  29 strains or lines available
References
Original:  J:86705 Koutnikova H, et al., Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14457-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/15/2020
MGI 6.15
The Jackson Laboratory