Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfrbtm9Sor
Name:	platelet derived growth factor receptor, beta polypeptide; targeted mutation 9, Philippe Soriano
MGI ID:	MGI:2682377
Synonyms:	F7, PdgfrbF7
Gene:	Pdgfrb  Location: Chr18:61178222-61218133 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Pdgfrbtm9Sor page

Germline Transmission:	Earliest citation of germline transmission: J:86542
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Hypomorph) Mutation:    Nucleotide substitutions   Mutation details: 7 point mutations were engineered and incorporated at the endogenous locus via homologous recombination of a targeting vector. Each mutation elicited a missense mutation, ablating tyrosine residues involved in Src, Grb2, PI3-K, RasGAP, SHP-2, and PLC-gamma signal transduction. Tyrosines at codons 578, 715, 739, 750, 770, and 1008 are substituted with phenylalanine, and a tyrosine at 1020 is substituted with isoleucine. A single FRT and loxP sites were left in introns 12 and 16, respectively. (J:86542)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:	84 strains or lines available

Original:	J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
All:	7 reference(s)