Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	ShhDsh
Name:	sonic hedgehog; short digits
MGI ID:	MGI:1861186
Synonyms:	Dsh, short digits
Gene:	Shh  Location: Chr5:28661838-28672099 bp, - strand  Genetic Position: Chr5, 14.39 cM
Alliance:	ShhDsh page

Strain of Origin:

(101 x C3H)F1

Allele Type:    Radiation induced Mutation:    Inversion   ShhDsh involves 138 genes/genome features (Gm42230, Cdhr17, Gm6673 ...) View all   Mutation details: The short digits mutation was shown to be allelic to Shh mutations by an alleleism test (Stefan Mundlos, unpublished, see also J:67151). This mutation is an inversion comprising 11.7 Mb. The distal breakpoint is 13.298 kb upstream of Shh, separating the coding sequence from several putative regulatory elements. The inversion results in dysregulated expression of Shh resulting in the mutant phenotype. (J:97323) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

21 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shh Mutation:	45 strains or lines available

Original:	J:14105 Selby P, et al., Short digits, a new mutation. Mouse News Lett. 1986;75:43
All:	5 reference(s)