Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Pde4dtm1Mct Name: phosphodiesterase 4D, cAMP specific; targeted mutation 1, Marco Conti MGI ID: MGI:2451168 Synonyms: 4DKO, PDE4D- Gene: Pde4d  Location: Chr13:108790711-110092503 bp, + strand  Genetic Position: Chr13, 59.69 cM Alliance: Pde4dtm1Mct page

Growth comparison of wild type and Pde4dtm1Mct/Pde4dtm1Mct mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58116
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.2 kb fragment encompassing exons 8 and 9 was replaced with a PGK-hrpt cassette inserted in the opposite orientation by homologous recombination. The deleted region encoded the catalytic domain. Neither transcript nor protein was detected in homozygous mutant brain tissue by Northern and Western blot analyses. (Corrected information communicated to MGI by author.) (J:58116)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pde4d Mutation:	181 strains or lines available

Original:	J:58116 Jin SL, et al., Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11998-2003
All:	24 reference(s)