Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ikzf1tm1.1(Pax5)Mbu
Name:	IKAROS family zinc finger 1; targeted mutation 1.1, Meinrad Busslinger
MGI ID:	MGI:2447787
Synonyms:	IkPax5
Gene:	Ikzf1  Location: Chr11:11634980-11722926 bp, + strand  Genetic Position: Chr11, 7.02 cM
Alliance:	Ikzf1tm1.1(Pax5)Mbu page

Germline Transmission:	Earliest citation of germline transmission: J:80815
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mutation details: The floxed neo cassette in exon 2 was removed by mating Znfn1a1tm1(Pax)Mbu animals to cre expressing line TgN(Sycp1-cre)4Min, thus allowing expression from the Pax5-GFP cassette inserted at Znfn1a1. Western blot analysis detected Pax5 protein expression in thymocytes and myeloid cells at levels similar to wild-type. GFP expression in B cells was detected by flow cytometric analysis. (J:80815)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf1 Mutation:	30 strains or lines available

Original:	J:80815 Souabni A, et al., Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 2002 Dec;17(6):781-93
All:	5 reference(s)