Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr3c1tm1Gsc
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, Gunther Schutz
MGI ID:	MGI:1857745
Synonyms:	GR-, GRhypo
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm1Gsc page

Germline Transmission:	Earliest citation of germline transmission: J:27441
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into exon 2. This allele is a hypomorphic allele; an mRNA containing an ORF encoding an amino-terminal truncated protein with intact DNA and ligand-binding domains is generated. (J:27441)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:27441 Cole TJ, et al., Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 1995 Jul 1;9(13):1608-21
All:	30 reference(s)