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Phenotypes Associated with This Genotype
Genotype
MGI:8408504
Allelic
Composition		 Polr1atm1c(EUCOMM)Hmgu/Polr1atm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J * C57BL/6N
Cell Lines HEPD0779_7_B03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (7 available); any Gt(ROSA)26Sor mutation (1243 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (24 available); any Gt(ROSA)26Sor mutation (1243 available)
Polr1atm1c(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:381064 )
• at E12, brightfield images of embryos (tamoxifen-induced at E9.5) show craniofacial malformations

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/06/2026
MGI 6.29 		The Jackson Laboratory