Phenotypes for Tg(Pdx1-cre)6Tuv Tle2 Tle3 MGI:7859479 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tle2^{tm1(KOMP)Vlcg}/Tle2^{tm1(KOMP)Vlcg} Tle3^tm1.1Pton/Tle3^tm1.1Pton Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pdx1-cre)6Tuv mutation (3 available)
Tle2^{tm1(KOMP)Vlcg} mutation (1 available); any Tle2 mutation (33 available)
Tle3^tm1.1Pton mutation (0 available); any Tle3 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:307817 )

• double knockout mice are glucose intolerant at 8 weeks of age, with no significant worsening of the Tle3 (Grg3) single knockout phenotype

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:307817 )

• pancreatic islets isolated from 7-mo-old double knockout mice show an obvious decrease in the number of INS+ beta cells that is similar to that in Tle3 (Grg3) single knockout mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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