Phenotypes Associated with This Genotype

Genotype
MGI:7797789

• Allelic Composition: Tg(Wnt1)1Hev/0; Zfp451^em1Ssli/Zfp451^em1Ssli
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor latency ( J:338905 )

• mice show delayed breast tumor initiation compared to single Tg(Wnt1)1Hev/0 mice

mortality/aging

increased tumor-free survival time ( J:338905 )

• mice show increased overall survival rates compared to single Tg(Wnt1)1Hev/0 mice

immune system

abnormal macrophage morphology ( J:338905 )

• mice exhibit a decrease in CD206+ macrophages compared to single Tg(Wnt1)1Hev/0 mice

decreased chemokine level ( J:338905 )

• tumor tissues express lower levels of CCL5 than those from single Tg(Wnt1)1Hev/0 mice

homeostasis/metabolism

decreased chemokine level ( J:338905 )

• tumor tissues express lower levels of CCL5 than those from single Tg(Wnt1)1Hev/0 mice

hematopoietic system

abnormal macrophage morphology ( J:338905 )

• mice exhibit a decrease in CD206+ macrophages compared to single Tg(Wnt1)1Hev/0 mice