Phenotypes Associated with This Genotype

Genotype
MGI:7790549

• Allelic Composition: Zfp574^em3Btlr/Zfp574^em3Btlr; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺; Tg(IghMyc)22Bri/0
• Genetic Background: B6.Cg-Ndor1^{Tg(UBC-cre/ERT2)1Ejb} Zfp574^em3Btlr Tg(IghMyc)22Bri

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:354285 )

• transplantation of a 1:1 mixture of mutant and wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit more rapid elimination of leukemic B cells than nonmalignant Zfp574^em3Btlr/Zfp574^em3Btlr Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mice; up to 79.3% of established leukemic B cells are eliminated after the first dose of tamoxifen and 91.9% of leukemic B cells are eliminated after a second tamoxifen dose

immune system

decreased B cell number ( J:354285 )

• transplantation of a 1:1 mixture of mutant and wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit more rapid elimination of leukemic B cells than nonmalignant Zfp574^em3Btlr/Zfp574^em3Btlr Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mice; up to 79.3% of established leukemic B cells are eliminated after the first dose of tamoxifen and 91.9% of leukemic B cells are eliminated after a second tamoxifen dose

neoplasm

decreased leukemia incidence ( J:354285 )

• transplantation of a 1:1 mixture of mutant and wild-type bone marrow cells into lethally irradiated CD45.1 recipients that were injected with tamoxifen 12 weeks after bone marrow transplantation exhibit more rapid elimination of leukemic B cells than nonmalignant Zfp574^em3Btlr/Zfp574^em3Btlr Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mice; up to 79.3% of established leukemic B cells are eliminated after the first dose of tamoxifen and 91.9% of leukemic B cells are eliminated after a second tamoxifen dose