Phenotypes Associated with This Genotype

Genotype
MGI:7764756

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: C.129S7(B6)-Rag1^tm1Mom/Tvg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence following infection ( J:329456 )

• Rauscher-like murine leukemia virus (RL-MuLV)-infected germ-free mutant mice show enhanced susceptibility to leukemia development, with about 85% (15/17) incidence of leukemia at 150 days compared to about 20% (13/71) in controls

• specific-pathogen free (SPF) mice exhibit increased RL-muLV-infection induced leukemia susceptibility compared with SPF controls

• however, both germ-free and specific-pathogen free mice show a similar frequency of infected splenocytes