About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:7764517
Allelic
Composition		 Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0
Zfp746tm1.1Tmd/Zfp746tm1.1Tmd
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO/Prnp-SNCA*A53T)4360Tmd mutation (1 available)
Zfp746tm1.1Tmd mutation (0 available); any Zfp746 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:327648 )
N
• mice injected with an adenovirus expressing tTA into the ventral midbrain show rescue of the dopamine neuron degeneration, loss of dopamine, and the loss of striatal dopamine fiber density, the prevention of amphetamine-induced rotation, and rescue of GFAP immunoreactivity seen in single Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory