Phenotypes Associated with This Genotype

Genotype
MGI:7764515

• Allelic Composition: Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased dopamine level ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show a reduction in dopamine and its metabolites

nervous system

astrocytosis ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain show an increase in GFAP immunoreactivity

loss of dopaminergic neurons ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show a robust loss of dopamine neurons

• mice injected with an adenovirus expressing tTA into the ventral midbrain show a reduction in striatal dopamine fiber density

• mice injected with an adenovirus expressing tTA into the ventral midbrain show an increase in amphetamine-induced rotational behavior, indicating loss of dopamine neurons

cellular

astrocytosis ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain show an increase in GFAP immunoreactivity