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Phenotypes Associated with This Genotype
Genotype
MGI:7763627
Allelic
Composition		 Kansl1em1Cya/Kansl1em1Cya
Tg(CAG-cre/Esr1*)5Amc/0
Igs2tm1(CAG-mt-Keima)Fink/Igs2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs2tm1(CAG-mt-Keima)Fink mutation (0 available); any Igs2 mutation (69 available)
Kansl1em1Cya mutation (0 available); any Kansl1 mutation (143 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitophagy ( J:327464 )
• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

homeostasis/metabolism
abnormal mitophagy ( J:327464 )
• hippocampal neurons treated with tamoxifen exhibit low mitophagic activity at 7 days in vitro

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory