Phenotypes Associated with This Genotype

Genotype
MGI:7719889

• Allelic Composition: Pkm^em1(IMPC)Bay/Pkm^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Pkm^em1(IMPC)Bay/Mmmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pkm^em1(IMPC)Bay/Pkm^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller with no formation of the egg cylinder and no primitive streak or hallmarks of gastrulation at E7.5.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos can be recovered at E7.5 (13% versus expected 25%, n=15); no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

absent egg cylinders ( J:279207 )

• no rudimentary egg cylinder has formed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5