Phenotypes Associated with This Genotype

Genotype
MGI:7705527

• Allelic Composition: Gt(ROSA)26Sor^{em1(CAG-Zbtb21,-GFP)Jhan}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Kln/0
• Genetic Background: B6.Cg-Gt(ROSA)26Sor^{em1(CAG-Zbtb21,-GFP)Jhan} Tg(Nes-cre)1Kln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:351206 )

♂ • mice show reduced freezing time during the contextual part of the fear conditioning test

impaired spatial learning ( J:351206 )

♂ • mice show longer latency to find the target during the Morris water maze training on day 4

abnormal spatial reference memory ( J:351206 )

♂ • in the Morris water maze probe test, mice spend less time in the target quadrant

nervous system

decreased dendritic spine density ( J:351206 )

♂ • mice show a reduction in spine density in the hippocampus

abnormal postsynaptic density morphology ( J:351206 )

♂ • mice show a reduction in post synaptic density in hippocampal CA1

abnormal CNS synaptic transmission ( J:351206 )

♂ • mice show reduced basal synaptic transmission in hippocampal CA1 region

abnormal excitatory postsynaptic potential ( J:351206 )

♂ • mice exhibit reduced fEPSP amplitude in hippocampal CA1 region

reduced long-term potentiation ( J:351206 )

♂ • mice show compromised LTP, with reduced fEPSP amplitude in hippocampal CA1 region